The Laboratory for Low-Carbon Energy and Environmental Sustainability promotes a long-term vision for the role of both technology and policy to cope with complex energy, environmental and natural resource challenges. The laboratory conducts systems research that addresses technical, economic and policy issues related to energy and the environment and fosters technological innovation. The systems research involves a combination of computational modeling for energy and environmental systems with engineering economics, life cycle assessment, risk analysis, policy analysis, and multi-criteria decision analysis in support of both technological and policy developments. Current interests of research mainly include carbon capture, utilization and storage, hydrogen energy, bioenergy, nuclear energy, and the energy-water nexus under carbon constraints for climate change mitigation. The laboratory pioneers the development of the Integrated Environmental Control Model (IECM), a publicly available computer tool used for power plant modeling and techno-economic assessment. The IECM has been applied by users from 55 countries since it was housed at the University of Wyoming in 2022.